MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post-transcriptional silencing of their complementary mRNA targets. Silencing is accomplished through a combination of translational suppression and destabilization of the targeted mRNA, with the latter contributing to most of the steady-state repression in animal cell cultures. MiRNAs can have broad-reaching cellular effects and have emerged as important regulators of various cellular processes.
世界杯365bet下载365bet滚球注册365bet体育投注正规Expression of miRNAs is altered in a variety of human cancers, and the alteration can affect various aspects of tumorigenesis. Our scientists are interested in identifying miRNAs that are deregulated during tumorigenesis, that regulate the expression of either oncogenes or tumor suppressor genes, that can modify tumorigenesis driven by classical oncogenic elements, that can influence treatment responses to either conventional chemotherapies or targeted therapies, and that can act as synthetic lethal agents to selectively kill cells that harbor a defined oncogenic alteration while sparing normal cells. We expect that our endeavors in this research field will lead to developing miRNAs as new therapeutics, therapeutic targets or diagnostic tools for the management of human cancer.